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Medicine

How a nerve signal crosses a synapse

Archive 01150

Slide 1

A chemical synapse passes a message between cells

A synapse is a communication junction. At a chemical synapse, a neuron, or nerve cell, releases a messenger that influences a neighbouring cell.

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An axon carries signals away from a neuron’s cell body toward its terminals. Dendrites commonly receive inputs, although real neural connections are more varied than this introductory pattern.

Slide 2

An electrical arrival triggers chemical release

When a signal reaches the nerve terminal, calcium can enter through channels. This helps small sacs called vesicles release neurotransmitter, a chemical messenger, into the gap.

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The gap is called the synaptic cleft. Messenger molecules cross it by diffusion and bind receptors on the receiving membrane; the two cells do not need to fuse together.

Slide 3

The receptor determines the receiving cell’s response

A neurotransmitter’s effect depends on the receptor it meets. A receiving cell may become more or less likely to send its own signal.

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A neuron combines inputs arriving at different locations and times. A small response from one connection need not be enough to initiate the larger electrical event called an action potential.

Slide 4

Clearing the messenger separates one event from the next

Messenger molecules are removed, taken back up or broken down. Clearing them helps a synapse distinguish one event from the next.

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Some synapses use direct electrical connections instead of a released chemical messenger. This alternative permits rapid transfer of current and can help synchronize groups of cells.

Slide 5

Changing connection strength changes the network

Synapses are adjustable communication points. Changes in their strength alter how a network responds to later patterns of activity.

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The nervous system also contains supporting cells called glia. Neurons depend on this surrounding tissue, so a network is more than a collection of isolated wires and switches.

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